What is AMPK and Why Should You Care?

  • Inhibits mTOR, which decreases cell growth and protein synthesis
  • Activates lipolysis and beta-oxidation (the breakdown of fat for energy)
  • Increases glucose uptake and glycolysis (the breakdown of glucose for energy)
  • Decreases glycogen storage and gluconeogenesis (formation of glucose from non-carbohydrate sources)
  • Initiate autophagy
  • Activates the transcription proteins in the control of autophagy and lysosomes (organelle responsible for degrading cellular debris)
  • Initiates “mitophagy” (turnover of damaged/aged mitochondria)
  • Increases mitochondrial biogenesis (formation of new mitochondria)
  1. Recycles old/damaged molecules
  2. Replenishes nutrient stores during times of starvation



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Kristi Storoschuk

Kristi Storoschuk

Science writer with a focus on ketogenic nutrition and metabolic therapies. www.getoldslowly.com