Here is a list of modern/chronic diseases associated with metabolic damage (i.e., mitochondrial dysfunction, insulin resistance, and metabolic inflexibility): Neurodegenerative disease: Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, ALS, multiple sclerosis Cancer Type-2 Diabetes Obesity Metabolic syndrome Cardiovascular disease Mental disorders (depression, anxiety, bipolar disorder, schizophrenia)